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Appendix E
View Study Lee, C., et al
This accumulation depletes the other types of folate required for purine and thymidylate synthesis, which are required for the synthesis of DNA
This impairment of DNA synthesis affects the rapidly dividing cells of the bone marrow earlier than other cells, resulting in the production of large, immature, hemoglobin-poor red blood cells (macrocytosis), as well as effects on white blood cells, including abnormal (hypersegmented) neutrophils and reduced overall cell counts (pancytopenia)
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