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It also activates the Nrf2 pathway, which upregulates antioxidant enzymes like CAT, SOD2, and HO-1, strengthening the cellular response to oxidative stress 197,199

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This modification facilitates its binding to histone acetyltransferases and ultimately inhibits PGC-1s transcriptional activity ( 2 = 0.68, 95% CI [0.96, 0.36], P = 0.0061