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The FDAs concern is twofold: Safety: Some substances are linked to toxicity, cardiac complications, or other serious adverse events

[29] Chauhan, A., Audhya, T

Precauciones y advertencias Antes de comenzar el tratamiento con Tirzepatide, los pacientes deben someterse a una evaluacin exhaustiva, que incluya: Evaluacin de la funcin renal, ya que la medicacin puede afectar la salud renal

Based on this statement, the Japanese Society of Hepatology recommends a computer-aided neuropsychological test (NPT), consisting of the number connection test-A, number connection test-B, digit symbol test, and block design test, as a gold standard test for CHE, with CHE diagnosed when at least two of these tests show abnormal performance [87]

There were no statistical differences in the demographics and characteristics of the participants between the two arms