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It is a two ATP-requiring enzymatically catalyzed process.[] After its synthesis, glutathione gets distributed in intracellular organelles, including endoplasmic reticulum (ER), nucleus, and mitochondria.[] NUCLEAR GLUTATHIONE In the nucleus, GSH prevents the oxidation of sulfhydryl groups of several proteins to disulfide groups

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Furthermore, exposure to extraneous factors such as UV radiation or various chemical agents may also contribute to this augmented ROS generation

Die hchsten Konzentrationen finden sich in der Leber (wichtigstes Organ fr die Entgiftung) und in Erythrozyten sowie in weien Blutzellen (Immunzellen)