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The most common "smart drugs" or nootropics on the marketfrom excessive caffeine to prescription stimulantsoperate through a mechanism we can call "neuro-depletion." When you consume a heavy nervous system stimulant, you force your brain to dump its reserves of neurotransmitters like dopamine and targeted norepinephrine

HUBERMAN: Maybe some of the nerve cells, the neurons there, are severed, okay, or crushed

10.1158/0008-5472.CAN-04-3494 Cancer Res

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Adverse Reactions/Side Effects Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B 12(see WARNINGS)