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doi: 10.1210/endocr/bqab098

Research documents that GHRP-6-induced appetite stimulation begins approximately 20 to 30 minutes after administration, peaks within the first hour, and generally subsides within 1 to 3 hours as GH levels normalize and ghrelin receptor stimulation diminishes

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The mechanism proposed by the originators is a peptideDNA / tissue-specific gene-expression effect: short bioregulator peptides are hypothesized to interact with chromatin and modulate gene expression in a target tissue