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Ethics declarations Ethics Approval This is a review article that does not require ethics approval as it solely analyzes previously published data

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Hypoglycaemia with glucose levels below 3.0 mmol/l (54 mg/dl) occurs much more often than previously appreciated [46, 101]

The pulsatile nature of GH release induced by this combination, rather than continuous elevation, has been identified as a key factor in maintaining receptor sensitivity and avoiding desensitization artifacts that can complicate long-term research protocols