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however, tirzepatide outperforms semaglutide due to its dual-pathway action

Blood Sugar Balance : By improving insulin sensitivity and preventing blood sugar spikes and crashes, GLP-1 can help stabilise energy levels and reduce the cravings often associated with blood sugar fluctuations

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For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable

In my private practice, I started using GLP-1 drugs such as exenatide in 2006 and liraglutide in 2010 for my patients with type 2 diabetes