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Semaglutide is not recommended for patients with severe gastrointestinal disease, including diabetic gastroparesis, according to the MHRA/EMC Summary of Product Characteristics

It works by: Blocking the reuptake of serotonin in the brain, increasing the availability of this neurotransmitter in the synaptic space Enhancing serotonergic neurotransmission , which helps regulate mood, anxiety, and emotional responses Sertraline is taken orally, typically once daily, and is metabolised in the liver by multiple cytochrome P450 enzymes, including CYP2B6, CYP2C19, CYP2D6, and CYP3A4

Semaglutide, suicidal ideation and behaviour: a resting state functional magnetic resonance imaging perspective