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Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

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Cardiovascular effects are characterized and mild: a transient systolic blood pressure increase of approximately 6 mmHg peaking at 2 to 4 hours post-dose, with a heart rate reduction of up to 5 beats per minute

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An adequate volume of fresh cultures were then inoculated into a set of 250-mL flasks containing 50 mL of liquid YPD medium to keep an initial optical density at 600 nm (OD 600 ) value of 0.2