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The article states that patients using or considering compounded semaglutide or tirzepatide should not substitute allulose as a replacement, because the clinical efficacy and magnitude of effect are fundamentally different

It includes incretin-based therapies where primary clinical positioning centers on weight management and excludes GLP-1 drugs prescribed solely for glycemic control without a labeled obesity indication

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In addition to the sensitivity and PMP criteria, the permutation-based test statistic was significant at a false discovery rate adjusted p -value 98% of participants