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J Biol Chem 1974

Diabetes Care 45 , 18331840 (2022)

Pergola PE, Rosenbaum DP, Yang Y, Chertow GM

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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway