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Notably, some studies have shown that vitamin K1 (chlorophylquinone) can compensate for the damage to the anti-ferroptosis defense mechanism when GPX4 was inhibited or when used with the DHODH inhibitor BQR, and its anti-ferroptosis efficacy was found to be equivalent to that of ferrostatin-1 (Fer-1) [61]

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Most of the studies occurred over 12 to 24 weeks, though, so this may not apply to long-term use