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Other gut-derived targets for pharmacotherapy Although GIP and GLP-1 have been identified as the most important humoral mediators of the incretin effect, other gut-derived factors are also involved in glucose and energy homoeostasis and may therefore qualify as future therapeutic targets [13] (Fig

Lactate in the regulation of tumor microenvironment and therapeutic approaches

10.3969/j.issn.1005-9202.2016.19.009 161 XuX

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Therefore, raising cellular NAD + through vitamin B3 family precursors or via drug-based interventions has become a broadly used strategy to restore mitochondrial and organismal homeostasis, with NAD + precursors becoming a popular supplementation approach