After combining TMT-labeled peptides, the mixed samples were desalted using a Sep-Pak cartridge (Waters), treated with Lambda phosphatase (Santa Cruz Biotechnology), and desalted again
With that proof of concept in hand, we then investigated the possibility of combining the peptide/oligourea hybrid approach with the protraction strategy, which consists of functionalizing a peptide with a fatty acid chain to promote its binding to albumin and prolong its in vivo half-life
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Upper arm injections should be administered by a caregiver