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Indeed, it has been shown that IFN (interferon a), IFN, TNF (tumor necrosis factor), and IL-1 (interleukin 1) are responsible for the exit of HSCs from quiescence 2,3,4,5,6

Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant

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