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Mol Cell Biol 2000

Crosstalk between STAT3, NF-B, and SMAD3 signaling STAT3, NF-B, and SMAD3 transcription factors are the main regulators of immune functions involving both the differentiation of immune cells and the modification of their different phenotypes and properties

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The peptide enhances dendritic spine formation, increases synaptic density, and facilitates long-term potentiation while reducing neuroinflammation through decreased IL-1 and TNF- expression and increased anti-inflammatory IL-10 levels