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It has been traditionally thought that exogenous GABA (i.e., taken as a supplement) does not cross the bloodbrain barrier, but data obtained from more recent research (2010s) in rats describes the notion as being unclear

doi: 10.1007/s00595-007-3706-2

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Ongoing Phase III trials, such as the TRIUMPH studies, aim to further evaluate retatrutides long-term safety and efficacy in diverse patient populations