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14) Niacinamide (Vit

[70] found in vivo and in vitro studies that GLP-1 and its analog exendin-4 were able to induce an increase in ABCA1 mRNA, increase the expression of apo AI mRNA and promoter, thereby increasing apo AI secretion, indicating that GLP-1 in hepatocytes may mediate the outflow of intracellular cholesterol to apo AI through the ABCA1 pathway

CREB signaling induces Bcl-2 (B- cell lymphoma) and BIRC3 (Baculoviral IAP repeat containing 3), a caspase protein, and exerts anti-apoptotic effects that in turn signal insulin receptors to release insulin [8]

Safety: Pycnogenol has been used in many studies for various conditions and has a strong safety record

Carta G, Murru E, Banni S, Manca C