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In a 90-day subchronic toxicity study, rats administered with coptisine (156 mg/kg/day in feed) exhibited body weight loss, altered liver and kidney function parameters, and histopathological changes in the liver, indicating that toxicity manifests only under long-term, continuous exposure rather than single dosing

T W Mak et al

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Increasing evidence points to oxidative stress, mediated by free radicals such as ROS and RNS, as a critical factor in the pathogenesis of these diseases [40]

The FDA said patients should also be monitored for depression or suicidal thoughts, and should stop taking Zepbound if symptoms develop