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Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

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Recently, however, methylcobalamin and adenosylcobalamin have become increasingly used in supplements because of their clear therapeutic advantages (see below)

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