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However, they also raise concerns regarding the long-term safety and ethical implications of its use
It primes the white cells that fight infection
Recent studies have shown the synergistic effect of ICD and ferroptosis in the tumor microenvironment, where tumor cells undergo immunogenic cell death and release immunogenic molecules, such as DAMPs, to recruit and activate immune cells and promote adaptive immune responses
The role of IECs in the coordination of immune pathways is largely dependent on their ability to express surface receptors, namely Toll-like receptors (TLRs), at their apical and basolateral membranes which are used to detect the presence of harmful stimuli (Abreu 2010