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The difference lies in tirzepatides ability to mimic the gastric-inhibitory polypeptide (GIP) hormone as well as the GLP-1 hormone

5.6 Severe Gastrointestinal Adverse Reactions Use of WEGOVY has been associated with gastrointestinal adverse reactions, sometimes severe [see Adverse Reactions (6)]

On the flip side, some patients report that tirzepatide actually gives them more energy as inflammation decreases and metabolic function improves

Because tirzepatide targets two hormones, it may help improve and manage blood sugar levels and cause more weight loss compared to GLP-1 receptor agonists alone