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Collectively these data provide a link between metformin, AMPK, LKB1, sirtuin-1, and cellular mechanisms that could enhance both healthspan and lifespan by reducing both cellular senescence and the activation of pro-proliferative pathways

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In November 2023, tirzepatide for chronic weight management was approved as Zepbound, with SURMOUNT trial data showing mean weight loss of roughly 21% at the 15 mg dose over 72 weeks

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Those are the treatments discussed above, which are nonsurgical, and are mostly focused on lasers, microneedling, injections, medications, and supplements