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Under normal conditions, TNF- is present at low levels in squamous epithelial cells, but its expression is markedly elevated in the esophageal and gastric mucosa of GERD patients

84 The AGERAGE axis activates the NF-B pathway, leading to increased production of pro-inflammatory cytokines and chemokines, which further exacerbates endothelial dysfunction and facilitates the transition to a mesenchymal phenotype

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