A review in Trends in Endocrinology & Metabolism asked: "Can kisspeptin be a new treatment for sexual dysfunction?" The authors highlighted therapeutic potential but noted the short half-life (~28 minutes) as the primary delivery challenge (ScienceDirect, 2025)
The Clinical Trial Data Weight Loss Results The clinical data for orforglipron is compelling
Crespo P, Litran R, Rojas TC, Multigner M, de la Fuente JM, Sanchez-Lopez JC, Garcia MA, Hernando A, Penades S, Fernandez A (2004) Permanent magnetism, magnetic anisotropy, and hysteresis of thiol-capped gold nanoparticles
That means someone losing 30 pounds might lose 8-10 of those pounds as muscle - which shows up as feeling weaker, more fatigued, and less functional than expected
The dose is also available through GoodRx for $399 per month