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A 2026 review in the American Journal of Sports Medicine emphasizes that despite popularity, "significant research regarding the safety and efficacy of these therapeutic methods is required before definitive recommendations can be made to patients." Only a single human case series exists for BPC-157 (for knee pain), with significant methodological flaws and no controls

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GHK-Cu stimulates blood vessel formation (angiogenesis), nerve outgrowth, and increases synthesis of collagen, elastin, and glycosaminoglycans

It may also decrease glucose-stimulated insulin secretion (GSIS), potentially leading to neonatal glucose dysregulation and associated risks

12 These outcomes are consistent with a maintained postprandial metabolic effect but note the important confound: in these trials cagrilintide is almost always studied with semaglutide, so cleanly attributing the postprandial glucose benefit to cagrilintides gastric or glucagon effects specifically is not straightforward