glp-1/gcgr dual agonist Understanding GLP-1 receptor agonists and their impact on drug discovery LY3437943, a novel triple glucagon,

Poyan Mehr, A

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The five subtypes are class A G-protein-coupled receptors signalling principally through Gs and adenylyl cyclase to raise intracellular cAMP, and the conserved His-Phe-Arg-Trp core of alpha-MSH is the message sequence recognised by the orthosteric pocket

This water-soluble tripeptide, made from the amino acids glycine, cysteine and glutamic acid, supports the cells in detoxification and helps protect them from damage caused by free radicals

Nat Rev Dis Prim 2017;3:17065