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[1] Often there are periods of illness, called flares, and periods of remission during which there are few symptoms

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In summary, PER1/2/3 and CRY1/2 are transcriptional repressors and interact with the CLOCK, NPAS2-ARNTL/BMAL1, or ARNTL2/BMAL2 heterodimer, inhibiting their activity (Carmona et al., 2020

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