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During activation, microglia typically upregulate proteins such as TREM2, APOE, and TYRO protein tyrosine kinase-binding protein (TYROBP)

It is a 37-residue C-terminally amidated peptide closed by a Cys2-Cys7 disulfide bridge, sequence KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH, with the Lys1 side chain acylated by a C20 fatty diacid through a gamma-glutamate linker

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