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(R) After PELI1 interference in NCI-H446 cells, Western blot analysis of Wnt3a, CD44, PRMT5, CRIP1, and PELI1 in total lysate, and nuclear -Catenin on day W8 after chemotherapy

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According to the FAERS public dashboard, some people who took tirzepatide later experienced health problems related to vision changes, including blurred vision, loss of vision in one eye, and tunnel vision

Mechanism Difference: Tirzepatide (Zepbound/Mounjaro): Dual GIP/GLP-1 receptor agonist Semaglutide (Wegovy/Ozempic): GLP-1 receptor agonist only Published Clinical Trial Data (Separate Studies): Tirzepatide (SURMOUNT-1): 16.0% to 22.5% mean weight loss at 72 weeks depending on dose Semaglutide (STEP trials): Approximately 15% mean weight loss at 68 weeks These trials were conducted separately with different patient populations and protocols