A full weekly dose hits your system all at once, triggers a spike in drug concentration, and sometimes brings nausea, bloating, or fatigue along for the ride
Position the pen
In a meta-analysis 6 of eight trials with 60080 patients (ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O) , treatment with a GLP-1 receptor agonist led to a 14% relative risk reduction in three-point MACE (HR 086 [95% CI 080093]
For beneficiaries accustomed to paying a $5 or $10 copay for their pharmaceuticals, a $50 copay could still be a big financial barrier
For CKD stages 35 (non-dialysis), the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines typically recommend 0.550.60 g/kg/day (0.60.8 g/kg in diabetes)