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Proton catalyzed nucleophilic substitution: To break the O-O bond in ROOH bond (where R is either a H or a lipid) and form a protein-cysteine sulfenic acid and ROH, there must be two conditions met
OxLDL components and their interaction with toll-like receptors (TLRs) 2 and 4, CD36 and other cellular receptors further mediate thromboinflammation enhancing tissue and organ damage culminating in organ failure, i.e., myocardial infarction, stroke, and pulmonary artery embolism (174, 209212)
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Han C, Yu G, Mao Y, Song S, Li L, Zhou L, et al
Around 7080% of GSH transport could be associated with DIC and OGC activity in the kidney, but only about 4550% of liver mitochondria [61]
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