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Those are the foundational signs of occupational burnout, which certainly affects our well-being in the workplace, but when unchecked, can also spill over into our personal lives. That spillover can show up as irritability, mood changes, social withdrawal or insomnia

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Melanoma cells serve as the source of several classical angiogenic growth factors including but not limited to vascular endothelial growth factor (VEGF), also known as the vascular permeability factor (VPF), fibroblast growth factor (FGF), interleukin-8 (IL-8), and placental growth factor (PlGF), all potent contributors of angiogenesis ( Figure 4 ) (85)

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