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Combination therapies Combination therapies that work via two mechanistically distinct targets to integrate immune modulation with a beta cell-specific component have been suggested [139,140,141] and encouraged [142]

In mice with diet-induced obesity, oral supplementation of 400mg/kg of butyrate improved glucose tolerance and increased the expression of phosphorylated adenosine monophosphate kinase (AMPK) as well as glucose transporter-4 in the adipose tissue, and reversed some of the gut microbiota alterations caused by the high-fat diet (HFD) (85)

In recent years, the pursuit of a sun-kissed complexion without the associated risks of ultraviolet (UV) exposure has led to the emergence of products like Melanotan

Acknowledgements This work is supported by Wellcome Trust/DBT India Alliance Fellowship (IA/I/16/2/502691) and SERB (CRG/2022/002149) awarded to R.A.S

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