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Compared to L-arginine, an advantage to supplementation with L-citrulline is that intestinal catabolism of L-citrulline is limited since it is not metabolized by arginases, and the activity of arginosuccinate synthase is low in enterocytes [2]

References: V

Not surprisingly, cell-specific features of eryptosis are rather associated with the clearance of the mitochondria in reticulocytes, and not with the enucleation process in RBC precursors during maturation