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Poor methylation has been linked to a wide range of health problems, including: Heart disease (1) Hormone imbalances Infertility Anxiety Depression (2) Autoimmune conditions and chronic inflammation (3) Chronic fatigue Autism spectrum disorder Elevated homocysteine levels Neurodegenerative diseases including Alzheimers (4) Type 2 diabetes and metabolic health (5) Some of the most compelling recent research on methylation has looked into the important role this process plays in cognitive function, and specifically forming and retrieving long-term memories