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Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acidproducing microbiota in the gut

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It is classified as a triple incretin receptor agonist, meaning it simultaneously targets three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors