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Generalizability Concerns Most clinical trials have been conducted in specialized research settings with intensive monitoring and support

Given that CoQ10 supplementation is typically used for non-urgent indications rather than essential medical treatment, a cautious approach is reasonable

Molecular docking and structure-based drug design strategies

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Accordingly, novel strategies aimed either at preventing mGSH depletion, such as mitochondrial cholesterol lowering agents for liver pathologies, or drugs capable of increasing mGSH levels need to be pursued from a therapeutic perspective