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Women should be aware that probiotic effects may take several weeks to become apparent, and individual responses vary considerably

Safety Considerations and Side Effects Whilst GLP-1 receptor agonists demonstrate good overall tolerability, patients and prescribers must understand potential adverse effects and safety considerations, particularly for menopausal women who may have age-related comorbidities

In the pivotal SURMOUNT-1 trial, participants without diabetes who took tirzepatide for 72 weeks lost an average of 16% of body weight at the 5 mg dose, 21.4% at the 10 mg dose, and 22.5% at the 15 mg dose, compared to just 2.4% in the placebo group

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