If you disbelieve the studies (which the failed replications support), then the dose question is moot
Approaches promising results without lifestyle modification
Flavonoids have been proven to protect -cell viability by limiting these gene expression changes ( Figure 4 ) ( Figure 4 Flavonoids, which include flavanols, flavonols, flavones, flavanones, isoflavones, and anthocyanins, also possess DPP-4 inhibitory activityfor instance, the flavonoid-rich fraction of Pilea microphylla displayed antidiabetic efficacy in rats with diabetes generated by a high-fat diet and streptozotocin by lowering DPP-IV
Skin Barrier Dysfunction Acne-prone skin is often stripped of its natural oils by harsh topicals, which worsens irritation and promotes rebound oiliness
26(2): S182 Zhang AQ, Mitchell SC, Ayesh R, et al