First came GLP-1 receptor agonists, then dual agonists targeting two hormonal axes, and now GLP-3s like retatrutide
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Small, frequent meals may be better tolerated than larger portions given the delayed gastric emptying induced by GLP-1 medications
It is evident that CNS GLP-1R signaling is essential for mediating the pharmacological action of GLP-1R agonists on energy metabolism as genetic deletion of CNS GLP-1R signaling in mice ablates the action of peripherally administered liraglutide on food intake and body weight reduction (Sisley et al., 2014)
