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For sermorelin, the beyond-the-endpoint discussion is mostly hypothetical in adults: proposed effects on sleep quality, body composition, or vitality are mechanistic extrapolations from GH-axis stimulation rather than trial-confirmed outcomes

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Fatigue is a potential side effect of semaglutide

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Similarly, although meal frequency was not explicitly tested in most trials, they say that strategies such as small, frequent meals may help reduce common side effects such as nausea and improve tolerability, especially in the early stages of treatment