7 Subcutaneous semaglutide was approved in 2021 and 2022 as Wegovy for weight loss in patients 12 and older after the STEP1 trial showed patients who took subcutaneous semaglutide had a -14.9% body weight reduction (-15.3kg) compared to -2.4% (-2.6kg) with placebo after 68 weeks
With long-acting weekly formulations, the prokinetic impairment persists for several days, such that omission of a single dose may not fully normalize gastric transit [2,7]
(2016) Autophagy promotes ferroptosis by degradation of ferritin, Autophagy , 12 , 1425-1428, doi: Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., and Jiang, X
Given its biological effects, activation of GLP-1R has been explored as a latent treatment for metabolic disorders like type 2 diabetes mellitus (T2DM) and obesity
10.1016/j.jacc.2023.10.03038199714 285 Cuenca JA, Balda J, Palacio A, et al