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Binding of the adaptor proteins Shc and the growth factor receptor substrates 2 (FRS-2) to Trk leads to the activation of the PI3K/Akt and MAPK pathways (35)

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These metabolic improvements appeared to start before significant weight loss was visible, suggesting that disrupting white fat vasculature has metabolic effects beyond simple fat reduction

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Available as a lyophilized powder in 10 mg vials, it is administered via daily subcutaneous injection