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We focus our discussion on derangements in glucose metabolism, cell respiration/mitochondrial function and changes to ketone and lipid metabolism/oxidation to emphasize potentially novel biomarkers for clinical outcome prediction and intervention and offer new insights into possible underlying mechanisms from preclinical research of TBI pathology

Oxidative stress and free radical accumulation may lead to sustained immunocyte challenge and result in depletion of intracellular glutathione

www.nature.com , Current Neuropharmacology , vol

In fact, some studies suggest that coffee consumption may even support certain antioxidant pathways in the liver