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The developing brain has limited antioxidant defenses and high metabolic demands, making it especially susceptible

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Cystine-mediated uptake is critical to cellular antioxidant stress, and xCT plays a major role in maintaining low concentrations of extracellular glutamate and cystine-mediated uptake

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Indeed, flux analysis showed that, similarly to GSH-sufficient MZB, Gclc -deficient FoB at rest showed decreased amounts of mitochondria-derived ATP (Fig