Some people, particularly those still in the titration phase or those sensitive to gastrointestinal effects, report mild increases in nausea
Several studies have demonstrated the potential of probiotics in cancer prevention through various mechanisms including modification of microbiota, neutralization of carcinogens, vitamin and short-chain fatty acids synthesis, improved gut barrier function, inhibition of cell proliferation, cell apoptosis, and anti-inflammatory and anti-pathogenic activity with effects on lowering tumor growth and metastasis
"Explosive, uncontrollable diarrhea
Mandlekar and Kong, 2001), was also significantly attenuated by GSTP1 (Supplementary Figure S4), which cannot be explained by GSTP1-mediated inactivation of reactive metabolites in the absence of bioactivation of tamoxifen in HepG2 cells
Nonetheless, due to biological and physiological differences between a small animal model and humans, such as a thinner cartilage, possible spontaneous healing of defects, biomechanics, and physical loading in small animals, thus, an additional chondral defect repair study using minipigs should be conducted to confirm these effects
