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The presence of a peak at 1,098 Da in the HRMS data (Supplementary Figure S6) corresponding to the fragment expected from cleavage of the amide bond between Lys17 and Ala18 further confirms trypsins enzymatic efficiency, as its activity depends on pH, temperature, and peptide structure

Por otra parte, TZP induce remisin de la esteatohepatitis asociada a disfuncin metablica (MASH) confirmada histolgicamente de forma dosis-dependiente (44-62% de casos, segn dosis) y mejora de al menos un estadio de fibrosis heptica en el 51-55% de los casos, cifras superiores a placebo45 (fig

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10.1080/13813450701661198 Arch Physiol Biochem