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Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists

It has strong salt tolerance, drought resistance, and water retention capabilities, and plays an active role in the ecological protection and construction of desert and grassland areas [5]

drug approval framework

These observations provide strong evidence for the proposed mechanism of action of these dual covalent degraders: covalent engagement of the target protein to lock it, followed by proteasomal degradation triggered by covalent modification of E3 ligases